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Toxic Crusaders is an action game released in 1992 for the Sega Mega Drive. Players take on the role of a mutated hero tasked with cleansing a toxic-ridden city from dangerous enemies and environmental hazards. The main objective involves navigating through various levels, defeating foes, and collecting items to progress further in the game.

The gameplay features a moderately fast pace that balances combat and exploration. A unique mechanic in Toxic Crusaders is the use of special attacks linked to the protagonist's mutated abilities, offering a variety of offensive options against the pollution-themed enemies. The game incorporates platforming elements alongside traditional beat-'em-up style combat, requiring players to adapt to both fighting and movement challenges.

One unusual idea in Toxic Crusaders is its environmental theme, where pollution and toxic waste are central to the setting and adversaries. This distinctive aspect contributes to the game's atmosphere, setting it apart from typical action titles of its era by blending eco-conscious motifs with gameplay. The combination of mutation-based powers and a polluted world creates a memorable experience on the Sega Mega Drive platform.