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Brain Drain is a puzzle game released in 1998 for the Game Boy. The main objective revolves around solving various brain teasers and logic puzzles to progress through increasingly challenging levels. Each stage requires players to carefully analyze clues and manipulate elements to unlock the next puzzle.

The game's pace is deliberately moderate, encouraging thoughtful problem-solving rather than quick reflexes. A unique mechanic involves the use of a mental map that helps players visualize connections between different puzzle components, adding a strategic layer to the gameplay. This mechanic supports deeper engagement with each puzzle and enhances the complexity of the challenges.

One distinctive aspect of Brain Drain is its focus on mental acuity over action, presenting a collection of diverse puzzle types within a compact handheld format. Unlike many puzzle games of its time, it incorporates a variety of puzzle styles, including pattern recognition and logic deduction, making it a versatile title for players interested in cognitive challenges.