Monsters, Inc. for the Game Boy Advance, released in 2001, is an action game that places players in the colorful world of the beloved animated film. The main objective revolves around navigating various levels as characters from the Monsters, Inc. universe, collecting items and overcoming obstacles to progress through the story. The gameplay emphasizes exploration and light combat, with a steady pace that balances challenge and accessibility.

A unique mechanic in this title involves using the characters' distinct abilities to solve puzzles and defeat enemies, encouraging players to switch strategies depending on the situation. The game also incorporates an unusual idea by blending platforming elements with item collection, creating a mix of action and strategy that keeps gameplay engaging.

One distinctive feature of Monsters, Inc. on the Game Boy Advance is its faithful adaptation of the film's aesthetic and characters into a handheld format, maintaining a vibrant and playful atmosphere. This helps immerse players in the Monsters, Inc. world while offering a compact and enjoyable gaming experience.