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Migrain is a puzzle game released in 1991 for the Game Boy platform. The main objective of the game is to solve increasingly complex puzzles by manipulating various elements on the screen to clear the board or achieve a specific configuration. Each level challenges the player to think strategically and use logic to progress.

The pace of Migrain is steady, allowing players to carefully plan their moves without time pressure. This deliberate tempo supports thoughtful problem-solving rather than quick reflexes. A unique mechanic in the game involves shifting blocks or tiles in patterns that affect multiple pieces at once, requiring players to anticipate the chain reactions their moves will trigger.

One distinctive feature of Migrain is its minimalist visual design combined with intricate puzzle layouts that encourage concentration and patience. The game’s unusual idea lies in its abstract puzzle concept, which departs from typical matching or block-dropping mechanics common in its era. This focus on cerebral challenges sets it apart within the puzzle genre on the Game Boy.